Scheherazade in Blue Jeans

(Yes, all you've been getting from me these days is science and perfume. I know.)

Septum keeps neurons in synch, can reduce epileptic seizures by 90 percent
Septum sets the tempo of brain's electrical activity

BETHESDA, MD (June 20, 2006) - The brain's septum helps prevent epileptic seizures by inducing rhythmical electrical activity in the circuits of another area of the brain known as the hippocampus, according to a new study in the Journal of Neurophysiology. The researchers found that, by imposing a normal "theta" rhythm on chronically epileptic rats, they could reduce epileptic seizures by 86-97 percent.

The study "Septo-hippocampal networks in chronically epileptic rats: Potential antiepileptic effects of theta rhythm generation," by Luis V. Colom, Antonio García-Hernández, Maria T. Castañeda, Miriam G. Perez-Cordova and Emilio R. Garrido-Sanabria, The University of Texas at Brownsville/Texas Southmost College, appears in the June issue of the Journal of Neurophysiology, published by The American Physiological Society.

The septum acts as the conductor, orchestrating brain impulses as they pass from the brain stem through the septum and on to the hippocampus, said the study's lead researcher, Luis V. Colom, of the University of Texas at Brownsville/Texas Southmost College. The hippocampus is a part of the brain that plays a role in memory, spatial navigation and sensory motor integration, among other functions.

Normally, the hippocampus oscillates at a frequency of 3-12 Hz, a frequency that is called the theta rhythm, Colom explained. Oscillations at theta frequency are important in processing and storing relevant sensory information and appears important to certain memory processes.

"My hypothesis is that the septum keeps the electrical activity of neurons within certain areas of the brain working within normal ranges," Colom said. "By keeping the neurons firing normally, the septum inhibits neuronal hyperexcitability, such as epilepsy, and hypoexcitablity, such as Alzheimer's disease." In addition, septal impulses may help to maintain the anatomical integrity of other brain structures.

( But wait! There's more! )

From the BBC - and yes, I'm reprinting the whole thing:

Cure for cancers 'in five years'

The hospital is appealing for donations to fund the research
Scientists in Manchester say a cure for all types of cancer could be available on the NHS within five years.

The world's first patient trials in a technique which genetically engineers cells will take place at the city's Christie Hospital later this year.

The treatment - gene-modified t-cell therapy - could replace more intrusive treatments like chemotherapy.

The cells are fitted with a "tracker" device to kill cancer cells before being injected back into the patient.

Professor Robert Hawkins, clinical director of Medical oncology at the hospital, says the initial results of lab tests have been "spectacular".

More traditional treatments like radiotherapy and chemotherapy destroy both healthy and cancerous cells.

The new system makes the body naturally seek out and kill tumours by boosting the infection-fighting t-cells.

The body does not naturally have enough of these cells to combat huge tumours, and cancer cells often develop protective mechanisms to avoid them being recognised by the body as a disease.

Doctors will take blood samples from cancer patients to extract t-cells. They then genetically modify the t-cells, attaching an antibody which works like a tracking device to enable the t-cells to zone in on cancer tumours.

The t-cells are then multiplied a thousand-fold over a two-week period and injected back into the patient's body.

Professor Hawkins is appealing for funds to build a lab to genetically engineer t-cells, so that the treatment can be available for patients that cancer drugs, chemotherapy and radiotherapy have already failed.

He said: "In the lab we have seen spectacular results in lung tumours and in the brain. It's remarkable.

"Given as an injection, it could get rid of a widespread range of tumours."

About £250,000 is needed through the Christie Appeal to pay for nurses with specialist training, research doctors and equipment.

Earlier this week, the hospital launched a new fundraising appeal backed by BBC One's Dr Who star, Christopher Eccleston, who was born in Salford.

Those wanting to give to the Christie Appeal can call the 24-hour donation line on 0800 1954321.

('song's note: If anyone finds a 'net-based or US-based way to donate, tell me! And thanks for passing this on, harkalark!)